Laboratory of Alexander Nikitin
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  • Fu, D.-J., Miller, A. D., Southard, T. L., Flesken-Nikitin, A., Ellenson, L. H., and Nikitin, A. Yu. (2018). Stem cell pathology. Annual Review of Pathology: Mechanisms of Disease. In press. 13: DOI: 10.1146/annurev-pathol-020117-043935.
  • Schmoeckel, E., Odai-Afotey, A., Schleißheimer, M., Rottmann, M., Flesken-Nikitin, A., Ellenson, L. H., Kirchner, T., Mayr, D., and Nikitin, A. Yu. (2017). LEF1 is preferentially expressed in the tubal-peritoneal junctions and is a reliable marker of tubal intraepithelial lesions. Modern Pathology. In press. NIHMS869901.
  • Sundberg, J. P., Boyd, K., HogenEsch, H., Nikitin, A. Yu., Treuting, P. M., and Ward, J. M. (2017). Training Mouse Pathologists: 15 Years of Workshops on the Pathology of Mouse Models of Human Disease Lab Animal. 46:204-206 PMID: 28422111 DOI: 10.1038/laban.1256.
  • Flesken-Nikitin, A. Harlan, B. A., and Nikitin, A. Yu. (2016). Transplantation into the mouse ovarian fat pad. JoVE, 115: e54444, doi: 10.3791/54444.
  • Harlan, B. A., and Nikitin, A. Yu. (2015). A quest for better mouse models of breast and ovarian cancers. EBioMedicine 2: 1268–1269. DOI: 10.1016/j.ebiom.2015.09.017. PMCID: 4634751.
  • Flesken-Nikitin, A., Odai-Afotey, A. A., and Nikitin, A. Yu. (2014). Role of the stem cell niche in the pathogenesis of epithelial ovarian cancers. Mol. Cell. Oncol. 1, e963435, DOI:10.4161/23723548.2014.963435.
  • Chinnam, M., Wang, Y., Zhang, X., Gold, D. L., Khoury, T., Nikitin, A. Y., Foster, B. A., Li, Y., Bshara, W., Morrison, C. D., Ondracek, R. P., Mohler, J., and Goddrich, D. (2014). The thoc1 ribonucleoprotein and prostate cancer progression. J. Natl. Cancer. Inst. 106. Oct 8;106(11). pii: dju306. doi: 10.1093/jnci/dju306. Print 2014 Nov.
  • Cheng, C-Y. Hwang, C.-I., Corney, D. C., Flesken-Nikitin, A., Jiang, L., Öner, G. M., Munroe, R. J., Schimenti, J. C., Hermeking, H., and Nikitin, A. Yu. (2014). miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Reports: 6, 1000–1007.
  • Cui, M., Augert, A., Rongione, M., Conkrite, K., Parazzoli, S., Nikitin, A. Yu., Ingolia, N., and MacPherson, D. (2014).PTEN is a potent suppressor of small cell lung cancer. Mol. Cancer Res. 12:654-659.  PMID: 24482365. PMCID: PMC4020961.
  • Adisetiyo, H., Liang, M., Liao, C.-P., Aycock-Williams, A., Cohen, M. B., Xu, S., Neamati, N., Conway, E. M., Cheng, C.-Y., Nikitin, A. Yu., and Roy-Burman, P. (2013). Genetic loss of Survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. PLOS ONE 8(7): e69484. doi:10.1371/journal.pone.0069484.
  • Flesken-Nikitin, A., Hwang, C.-I., Cheng, C-Y., Michurina, T. V., Enikolopov, G., and Nikitin, A. Yu. (2013). Ovarian surface epithelium at the junction area contains cancer-prone stem cell niche. Nature 495: 241–245.
  • Cheng, C.-Y., Zhou, Z., and Nikitin, A. Yu. (2013). Detection and organ-specific ablation of neuroendocrine cells by synaptophysin locus-based BAC cassette in transgenic mice. PLOS ONE 8:e60905- doi:10.1371/journal.pone.0060905.
  • Jesty, S. A., Steffy, M. A., Lee, F. K., Breitbach, M., Hesse, M., Reining, S., Lee, J., Doran, R. M., Nikitin, A. Yu., Fleischmann, B. K., and Kotlikoff, M. I. (2012). c-kit+ precursors support post-infarction myogenesis in the neonatal, but not adult, heart. Proc. Natl. Acad. Sci. USA 109:13380-12285.
  • Chandler, E. M., Seo, B. R., Califano, J. P., Andresen Eguiluz, R. C., Lee, J. S., Yoon, C. J., Tims, D. T., Wang, J. X., Cheng, L., Mohanan, S., Buckley, M. R., Cohen, I., Nikitin, A. Yu., Williams, R. M., Gourdon, D., Reinhart-King, C. A., and Fischbach, C. (2012). Implanted adipose progenitor cells as physicochemical regulators of breast cancer. Proc. Natl. Acad. Sci. USA, 109:9786-9791.
  • HogenEsch, H., and Nikitin, A. Yu. (2012). Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal models. J. Controlled Release. 164:183-186.
  • Sundberg, J. P., Ward, J. M., HogenEsch, H., Nikitin, A. Yu., Treuting, P. M., Macauley, J. B., and Schofield, P. N. (2012). Training pathologists in mouse pathology. Vet. Pathology. 49:393-397.
  • Migone, F., Ren, Y., Cowan, R. G., Harman, R. M., Nikitin, A. Yu., and Quirk, S. M. (2012). Dominant activation of the Hedgehog signaling pathway alters development of the female reproductive tract. Genesis 50:28-40.
  • Sundberg, J. P., HogenEsch, H., Nikitin, A. Yu., Treuting, P., and Ward, J. M. (2012). Training Mouse Pathologists: 10 Years of Workshops on the Pathology of Mouse Models of Human Disease. Tox. Pathology. 40:823-825.
  • Gu, X., Kaushik, T., Vedvyas, Y. Hwang, C.-I. Hu, X., Nikitin, A. Yu., and Jin, M. M. (2012). Monoclonal antibody against ephrin-B2 for detection of tumor and neovasculature, and gene delivery application. PLOS One. 7: e30680.
  • Hwang, C.-I., Matoso, A., Corney, D. C., Flesken-Nikitin, A., Körner, S., Wang, W., Boccaccio, C., Thorgeirsson, S. S., Comoglio, P. M., Hermeking, H., and Nikitin, A. Yu. (2011). Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc. Natl. Acad. Sci. USA. 108:14240-14245.
  • Bolon, B., Altrock, B., Barthold, S., Baumgarth, N., Besselsen, D., Boivin, G., Boyd, K., Brayton, C., Cardiff, R., Couto, S, Eaton, K., Foreman, O., Griffey, S., La Perle, K., Lairmore, M., Liu, C., Meyerholz. D., Nikitin, A. Yu., Schoeb, T., Schwahn, D., Sellers, R., Sundberg, J., Tolwani, R., Valli, V., and Zink, M. C. (2011). NIH plan will hinder translational studies. Nature 47: 36–37.
  • Bolon, B., Altrock, B., Barthold, S., Baumgarth, N., Besselsen, D., Boivin, G., Boyd, K., Brayton, C., Cardiff, R., Couto, S, Eaton, K., Foreman, O., Griffey, S., La Perle, K., Lairmore, M., Liu, C., Meyerholz. D., Nikitin, A. Yu., Schoeb, T., Schwahn, D., Sellers, R., Sundberg, J., Tolwani, R., Valli, V., and Zink, M. C. (2011). Advancing translational research. Science 331: 1516-1517.
  • Cheng, C-Y., and Nikitin, A. Yu. (2011) Neuroendocrine cells: potential cells of origin for small cell lung carcinoma. Cell Cycle, 10:3629-3630.
  • Hwang, C.-I., Choi, J., Zhou, Z., Flesken-Nikitin, A., Tarakhovsky, A., and Nikitin, A. Yu. (2011). MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF. Cell Cycle 10:3834 - 3840.
  • Sun, H., Wang, Y., Chinnam, M., Zhang, X., Hayward, S. W., Fosrter, B. A., NIkitin, A. Yu., Willis, M., and Goodrich, D. W. (2011). An E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc. Natl. Acad. Sci. USA. 108:704-709.
  • Cheng, L., Ramesh, A. V., Flesken-Nikitin, A., Choi, J. and Nikitin, A. Yu. (2010). Mouse models for cancer stem cell research. Tox. Pathology. 38: 62-71.
  • Kaufman M. H., Nikitin, A. Yu., and Sundberg, J. P. (2010). Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis. CRC Press. Boca Raton, FL., 232 p.
  • Li, B., Antonyak, M. A., Druso, J. E., Cheng, L., Nikitin, A. Yu., and Cerione, R. A. (2010). EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc. Natl. Acad. Sci. U S A. 107: 1408–1413.
  • Corney, D. C., Hwang, C., Matoso, A., Vogt, M., Flesken-Nikitin, A., Godwin, A. K., Kamat, A. A., Sood, A. K., Hermeking, H., , Ellenson, L., H., and Nikitin, A. Yu. (2010). Frequent downregulation of miR-34 family in human ovarian cancers. Clin. Cancer Res. 16: 1119–1128.
  • Liao,C.-P., Liang, M., Cohen, M. B., Flesken-Nikitin, A., Jeong, J. H., Nikitin, A. Yu., and Roy-Burman, P. (2010). Mouse prostate cancer cell lines established from primary and post-castration recurrent tumors. Hormones and Cancer. 1: 44-54.
  • Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Yu., and Ghosh, J. (2010). Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. Int. J. Oncol. 36:1419-1428.
  • Williams, R. M., Flesken-Nikitin, A., Ellenson, L. H., Connolly, D. C., Hamilton, T. C., Nikitin, A. Yu., and Zipfel, W. R. (2010). Strategies for high resolution imaging of epithelial ovarian cancer by laparoscopic nonlinear microscopy. Translational Oncology. 3:181-194.
  • Cheng, L., Zhou, Z., Flesken-Nikitin, A., Toshkov, I. A., Wang, W., Camps, J., Ried, T. and Nikitin, A. Yu. (2010). Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene 29:5700-5071.
  • Liu, K., Cheng, L., Flesken-Nikitin, A., Huang, L., Nikitin, A. Yu., and Pauli, B. U. (2010). Conditional knockout of fibronectin abrogates mouse mammary gland lobulo-alveolar differentiation. Developmental Biology 6:11-24.
  • Choi, J., Curtis, S., Roy, D. M., Flesken-Nikitin, A., and Nikitin, A. Yu. (2010). Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am. J. Pathology. 177:2645-2658.
  • Nafus, M. G., and Nikitin, A. Yu. (2009). Cancer stem cells in solid tumours. In Eds. Dittmar, T. and Zänker, K. Stem Cell Biology in Health and Disease. Springer, Springer, Dordrecht, p. 295-326.
  • Nikitin, A. Yu., Nafus, M. G., Zhou, Z., Liao, C.-P., and Roy-Burman, P. (2009). Prostate stem cells and cancer in animals. In Eds. Bagley, R. G. and Teicher, B. A. Stem Cells and Cancer. Humana Press, p.199 - 216.
  • Matoso, A., Zhou, Z, Hayama, R., Flesken-Nikitin, A., and Nikitin, A. Yu. (2008). Cell lineage-specific genetic interactions between Men1 and Rb in neuroendocrine neoplasia. Carcinogenesis 29:620-628.
  • Xu, X., Page, J.L., Surtees, J.A., Liu, H., Lagedrost, S., Lu, Y., Bronson, R., Alani, E., Nikitin, A. Yu., and Weiss, R.S. (2008) Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Res. 68:2652-2660.
  • Antoch, M. P., Gorbacheva, V. Y., Vykhovanets, O., Toshkov, I. A., Kondratov, R. V.,  Kondratova, A. A., Lee, C., and Nikitin, A. Yu. (2008). Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7: 1197-1204.
  • Vias, M., Massie, C., E., East, P., Scott, H., Warren, A., Zhou, Z., Nikitin, A. Yu., Neal, D.E. and Mills, I. G. (2008). Pro-neural transcription factors as cancer markers. BMC Medical Genomics 2008, 1:17.
  • Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Yu., and Noy, N. (2008). Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR. Proc. Natl. Acad. Sci. USA. 105:7546-7551.
  • Corney, D. C., Flesken-Nikitin, A., Choi, J. and Nikitin, A. Yu. (2008). Role of p53 and Rb in ovarian cancer. Adv Exp Med Biol. 622:99 -117.
  • Corney, D. C., and Nikitin, A. Yu. (2008). MicroRNA and ovarian cancer.  Histol. Histopathol. 23: 1161-1169.
  • Ince, T. A., Ward, J. M., Valli, V. E., Sgroi, D., Nikitin, A. Yu., Loda, M. F., Griffey, S. M., Crum, C. P., Crawford, J. M., Bronson, R. T., Brayton, C., and Cardiff, R. D. (2008). “Do-it-yourself (DIY) Pathology". Nature Biotechnology. 26:978-979.
  • Matoso, A., and Nikitin, A. Yu. (2008). Cancer stem cells in solid tumors. In Eds. Dittmar, T. and Zänker, K. S. Cancer and Stem cells. Nova Science, New York. p. 87-110.
  • Sundberg, J. P., Hackman, R. C., HogenEsch, H., Nikitin, A. Yu., and Ward, J. M. (2007). Training mouse pathologists: Five years of pathology of mouse models of human disease workshops. Tox. Pathology. 35:699-707.
  • Nikitin, A. Yu., Matoso, A., and Roy-Burman, P. (2007). Prostate stem cells and cancer. Histol. Histopathol. 22: 1043-1049.
CR_07
  • Zhou, Z., Flesken-Nikitin, A. and Nikitin, A. Yu. (2007). Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res. 67:5683-5690.
  • Barthold, S. W.,  Borowsky, A. D.,  Brayton, C., Bronson, R.,  Cardiff, R. D., Griffey, S. M.,  Ince, T. A., Nikitin, A. Yu., Sundberg, J., Valli, V. E., and Ward, J. M. (2007). From whence will they come? – A perspective on the acute shortage of pathologists in biomedical research. J. Vet. Diagnostic Invest. 19:455-456.
  • Liao, C.-P., Zhong, C., Saribekyan, G., Bading, J., Park, R., Conti, P. S., Moats, R.,  Berns, A., Shi, W., Zhou, Z., Nikitin, A. Yu., and Roy-Burman, P. (2007). Mouse models of prostate adenocarcinoma with capacity for monitoring spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 67:7055-7546.
  • Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W. and Nikitin, A. Yu. (2007). MicroRNA-34b and -34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433-8438.
  • Flesken-Nikitin, A., Toshkov, I.A., Nascar, J., Tyner, K. M., Williams, R. M., Zipfel, W. R., Giannelis, E., and Nikitin, A. Yu. (2007). Toxicity and biomedical imaging of layered nanohybrids in the mouse. Tox. Pathology 35: 804-810.
  • Choi, J., Burns, A. A., Williams, R. M., Zhou, Z., Flesken-Nikitin, A., Zipfel, R. W., Wiesner, U., and Nikitin, A. Yu. (2007). Core-shell silica nanoparticles as fluorescent biological labels for nanomedicine applications. J. Biomed. Optics 12: 064007.
  • Valli, T., Barthold, S. W., Ward, J. E., Brayton, C., Nikitin, A. Yu., Borowsky, A. D., Bronson, R. T., Cardiff, R. D., Sundberg, J., and Ince, T. (2007). Over 60% of NIH extramural funding involves animal-related research. Vet. Pathology 44: 962-963.
  • Kichina, J. V., Zeremski, M., Aris, L., Gurova, K. V., Walker, E., Franks, R., Nikitin, A. Yu. Kiyokawa, H., and Gudkov, A. V. (2006). Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene 25:857-866.
  • Daikoku, T., Tranguch, S., Trofimova, I. N., Dinulescu, D. M., Jacks, T., Nikitin, A. Yu., Connolly, D. C., and Dey, S. K. (2006). Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res.66:2527-2531.
  • Zhou, Z., Flesken-Nikitin, A., Corney, D. C., Wang, W., Goodrich, D. W., Roy-Burman, P. and Nikitin, A. Yu. (2006). Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res. 66:7889-7898.
  • Cardiff, R. D., Anver, M. R., Boivin, G. P., Bosenberg, M. W., Maronpot, R. R., Molinolo, A. A., Nikitin, A. Yu., Rehg, J. E., Thomas, G. V., Russell, R. G., and Ward, J. M. (2006). Precancer in mice: Animal models used to understand, prevent, and treat human precancers. Tox. Pathology. 34:699-707, 2006.
  • Flesken-Nikitin, A., Williams, R. M., Zipfel, W. R., Webb, W.W. and Nikitin, A. Yu. (2005). Use of multiphoton imaging for studying cell migration in the mouse. In: Ed. Guan, J.-L. Methods in Molecular Biology, vol. 294: Cell Migration: Developmental Methods and Protocols. Humana Press Inc., Totowa , NJ . p. 335 - 344.
  • Zhou, Z., Flesken-Nikitin, A., Levine, C. G., Shmidt, E. N., Eng, J. P., Nikitina, E. Yu., Spencer, D. M., and Nikitin, A. Yu. (2005). Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary anterior lobe tumors and medullary thyroid carcinomas in Rb+/- mice. Cancer Res. 65:787-796.
  • Nikitin, A. Yu., and Hamilton, T. C. (2005). Modeling ovarian cancer in the mouse. In: Ed. Mohan, R.M. Research Advances in Cancer. Global Research Network, Kerala, 49-59.
  • Shmidt, E. N., and Nikitin, A. Yu. (2004). Pathology of mouse models of human lung cancer. Comp. Medicine, 54: 23-26.
  • Nikitin, A. Yu. , Connolly, D. C., and Hamilton, T. C. (2004). Pathology of ovarian neoplasms in genetically modified mice. Comp. Medicine, 54: 26-28.
  • Nikitin, A. Yu. , Alcaraz, A., Anver, M., Bronson, R. T., Cardiff, R. D., Dixon, D., Fraire, A. E., Gabrielson, E. W., Gunning, W. T., Haines, D. C., Kaufman, M. H., Linnoila, I., Maronpot, R. R., Rabson, A. S., Reddick, R. L., Rehm, S., Rozengurt, N., Schuller, H. M., Shmidt, E. N., Travis, W. D., Ward, J. M., and Jacks, T. (2004). Classification of proliferative pulmonary lesions of the mouse: Recommendations of the Mouse Models of Human Cancers Consortium. Cancer Res., 64: 2307-2316.
  • Lin, S.-C. J, Lee, K.-F., Nikitin, A. Yu. , Hilsenbeck, S. G., Cardiff, R. D., Li, A. Kang, K.-W., Frank, S. A., Lee, W.-H., and Lee E. Y.-H. (2004). Somatic mutation of p53 leads to estrogen receptor a-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 64, 3525-3532.
  • Kurie, J. M., Minoo, P., Hecht, S.S., Nikitin, A. Yu. , and DeMayo, F.J. (2004). Lung cancer. In: Ed. Holland, E. C. Mouse Models of Human Cancer. Wiley-Liss. New Jersey. p. 83-102.
  • Sharp, Z. D., Lee, W.-H., Nikitin, A. Yu., Flesken-Nikitin, A., Ikeno, Y., Reddick, R., Richardson, A. G., and Nelson J. F (2003). Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis, 24: 179-183.
  • Connolly, D. C., Bao, R., Nikitin, A. Yu., Stephens, K. C., Poole, T., Hua, X., Hanahan, D., Vanderhyden, B., and Hamilton, T. C. (2003). Female mice chimeric for the expression of the SV40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res., 63: 1389-1397.
  • Zipfel, W. R., Williams, R. M., Christie, R., Nikitin, A. Yu., Hyman, B. T., and Webb, W. W. (2003). Live tissue intrinsic emission microscopy using multiphoton-excited fluorescence and second harmonic generation. Proc. Natl. Acad. Sci. USA, 100: 7075-7080.
  • Flesken-Nikitin, A., Choi, K.-C., Eng, J. P., Shmidt, E. N. and Nikitin, A. Yu. (2003). Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res., 63: 3459-3463.
  • Manor, D., Shmidt, E. N., Budhu, A., Flesken-Nikitin, A., Zgola, M., Page, R., Nikitin, A. Yu., and Noy, N. (2003). Suppression of mammary tumor growth by cellular retinoic acid binding protein-II. Cancer Res., 63: 4426-4433.
  • Hamilton, T. C., Connolly, D. C., Nikitin A. Yu., Garson, K., and Vanderhyden, B. C. (2003) Translational research in ovarian cancer: a must. Int. J. Gynecol. Cancer, 2003 13 (Suppl 2): 220-230.
  • Nikitin, A. Yu., Liu, C.-Y., Flesken-Nikitin, A., Chen, C.-F., Chen, P.-L., and Lee, W.-H. (2002). Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2-/-Rb+/- mice. Cancer Res., 62: 5134-5138.
  • Tsai, K. Y., MacPherson, D., Rubinson, D., A., Nikitin, A. Yu., Bronson, R., Mercer, K. L., Crowley, D., and Jacks, T. (2002). ARF mutation accelerates pituitary tumor development in Rb+/- mice. Proc. Natl. Acad. Sci. USA, 99: 16865-16870.
  • Nikitin, A. Yu., Shan, B., Flesken-Nikitin, A., Chang, K.-H., and Lee, W.-H. (2001). The retinoblastoma gene regulates somatic growth during mouse development. Cancer Res. 61: 3110-3118.
  • Utomo, A. R. H., Nikitin, A. Yu., and Lee W.-H. (1999). Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nature Biotechnology, 17: 1091-1096.
  • Nikitin, A. Yu., Riley, D. J., and Lee W.-H. (1999). A paradigm for cancer treatment using the retinoblastoma gene in a mouse model. Ann. NY Acad. Sci., 886: 12-22.
  • Nikitin, A. Yu., Juárez-Pérez. M. I., Li, S., Huang, L., and Lee W.-H. (1999). RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice. Proc. Natl. Acad. Sci. USA, 96: 3916-3921.
  • Nikitin, A. Yu., Riley, D. J., and Lee, W.-H. (1997). Earlier onset of melanotroph carcinogenesis in mice with inherited mutant paternal allele of the retinoblastoma gene. Cancer Res., 57:4274-4278.
  • Riley, D. J., Nikitin, A. Yu., and Lee, W.-H. (1996). Adenovirus-mediated, retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice. Nature Medicine, 2: 1316-1321.
  • Nikitin, A. Yu., and Lee, W.-H. (1996). Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice. Genes Devel., 10: 1870-1879.
  • Nikitin, A. Yu., Rajewsky, M. F., and Pozharisski, K. M. (1993). Development of malignant fibrous histiocytoma induced by 7,12-dimethylbenz [a] anthracene in the rat: Characterization of early atypical cells. Virchows Arch. [B]. 64:151-159.
  • Nikitin, A. Yu., Lennartz, K., Pozharisski, K. M., and Rajewsky M. F. (1991). Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Differentiation 48: 33-42.
  • Nikitin, A. Yu., Ballering, L. A. P., Lyons, J., and Rajewsky, M. F. (1991). Early mutation of the neu (erb B-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage. Proc. Natl. Acad. Sci. USA 88: 9939-9943.