Publications

Publications

Complete List of Published Work:

https://www.ncbi.nlm.nih.gov/myncbi/alexander.nikitin.1/bibliography/public/

 Select List:

  • Flesken-Nikitin A., Pirtz M. G., Ashe C. S., Ellenson L. H., Cosgrove B. D., Nikitin A. Yu. (2024). Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis. bioRxiv doi: doi.org/10.1101/2024.03.15.585274.
  • Flesken-Nikitin, A., Ralston, C. Q., Fu, D.-J., McKellar, D., De Micheli, A. J., Phuong, D. J., Harlan, B. H., Armstrong, A. P., Ghuwalewala, S., Schimenti., J. C., Cosgrove, B. D., and Nikitin, A. Yu. (2024). Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma. Nature Communications 15:8641. doi.org/10.1038/s41467-024-52984-1.
  • Penfold, L., Woods, A., Pollard, A. E., Arizanova, J., Eneko Pascual-Navarro, Muckett, P.J., Dore, M. H., Montoya, A., Whilding, C., Fets, L., Mokochinski, J., Constantin, T. A., Carver, A. V., Bevan, C. L., Nikitin, A. Yu., Hall, Z., and Carling, D. (2023). AMPK activation protects against prostate cancer by inducing a catabolic cellular state. Cell Reports, 42, 112396, doi: 10.1016/j.celrep.2023.112396 PMID: 37061917.
  • Dixon, D. and Nikitin, A. Yu. (2022). Female reproductive system. In Eds. Sundberg, J. P., Vogel, P, and Ward, J. M. Pathology of Genetically Engineered and Other Mutant Mice. Wiley, Hoboken, NJ. p. 403-430.
  • Yamulla, R. J., Nalubola, S., Flesken-Nikitin, A., Nikitin, A. Yu., and Schimenti, J. C. (2020). Most commonly mutated genes in high-grade serous ovarian carcinoma are nonessential for ovarian surface epithelial stem cell transformation. Cell Reports, 32: 108086. doi.org/10.1016/j.celrep.2020.108086.
  • Rose, I. M., Bidarimath, M., Webster, A., Godwin, A. K., Flesken-Nikitin, A., and Nikitin, A. Yu. (2020). WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations. Sci. Rep. 10:9837. doi.org/10.1038/s41598-020-66556-y PMID: 32555344.
  • Cheng, C. Y., Zhou, Z., Stone, M., Lu, B., Flesken-Nikitin, A., Nanus, D. M., and Nikitin, A. Yu. (2020). Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells. Oncogenesis 9:38 doi.org/10.1038/s41389-020-0222-3. PMID: 32205838 PMCID: PMC7090072.
  • Fu, D.-J., Wang, L., Chouairi, F. K., Rose, I. M., Abetov, D. A., Miller, A. D., Yamulla, R. J., Schimenti, J. C., Flesken-Nikitin, A., and Nikitin, A. Yu. (2020). Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells. Nature Communications. 11:84. doi.org/10.1038/s41467-019-13847-2. PMID: 31901081, PMCID: PMC6941991.
  • Fu, D.-J., De Micheli, A., Harlan, B. H., Bidarimath, M., Ellenson, L. H., Cosgrove, B. D., Flesken-Nikitin, A., and Nikitin, A. Yu. (2020). Cells expressing PAX8 are the main source of homeostatic regeneration of adult endometrial epithelium and give rise to serous endometrial carcinoma. Dis. Model. Mech. 13(10):dmm047035. doi: 10.1242/dmm.047035. PMID: 32998907 PMCID: PMC7648606.
  • Fu, D.-J., Miller, A. D., Southard, T. L., Flesken-Nikitin, A., Ellenson, L. H., and Nikitin, A. Yu. (2018). Stem cell pathology. Annual Review of Pathology: Mechanisms of Disease. 13:4.1–4.22. PMID: 29059010.
  • Schmoeckel, E., Odai-Afotey, A., Schleißheimer, M., Rottmann, M., Flesken-Nikitin, A., Ellenson, L. H., Kirchner, T., Mayr, D., and Nikitin, A. Yu. (2017). LEF1 is preferentially expressed in the tubal-peritoneal junctions and is a reliable marker of tubal intraepithelial lesions. Modern Pathology.30:1241-1250. PMID: 28664938 PMCID: PMC5604248.
  • Flesken-Nikitin, A. Harlan, B. A., and Nikitin, A. Yu. (2016). Transplantation into the mouse ovarian fat pad. JoVE, 115: e54444, DOI: 10.3791/54444.
  • Flesken-Nikitin, A., Odai-Afotey, A. A., and Nikitin, A. Yu. (2014). Role of the stem cell niche in the pathogenesis of epithelial ovarian cancers. Mol. Cell. Oncol. 1, e963435, doi:10.4161/23723548.2014.963435.
  • Cheng, C-Y. Hwang, C.-I., Corney, D. C., Flesken-Nikitin, A., Jiang, L., Öner, G. M., Munroe, R. J., Schimenti, J. C., Hermeking, H., and Nikitin, A. Yu. (2014). miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Reports: 6, 1000–1007.
  • Flesken-Nikitin, A., Hwang, C.-I., Cheng, C-Y., Michurina, T. V., Enikolopov, G., and Nikitin, A. Yu. (2013). Ovarian surface epithelium at the junction area contains cancer-prone stem cell niche. Nature 495: 241–245.
  • Cheng, C.-Y., Zhou, Z., and Nikitin, A. Yu. (2013). Detection and organ-specific ablation of neuroendocrine cells by synaptophysin locus-based BAC cassette in transgenic mice. PLOS ONE 8:e60905- doi:10.1371/journal.pone.0060905.
  • Hwang, C.-I., Matoso, A., Corney, D. C., Flesken-Nikitin, A., Körner, S., Wang, W., Boccaccio, C., Thorgeirsson, S. S., Comoglio, P. M., Hermeking, H., and Nikitin, A. Yu. (2011). Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc. Natl. Acad. Sci. USA. 108:14240-14245.
  • Hwang, C.-I., Choi, J., Zhou, Z., Flesken-Nikitin, A., Tarakhovsky, A., and Nikitin, A. Yu. (2011). MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF. Cell Cycle 10:3834 – 3840.
  • Corney, D. C., Hwang, C., Matoso, A., Vogt, M., Flesken-Nikitin, A., Godwin, A. K., Kamat, A. A., Sood, A. K., Hermeking, H., , Ellenson, L., H., and Nikitin, A. Yu. (2010). Frequent downregulation of miR-34 family in human ovarian cancers. Cancer Res. 16: 1119–1128.
  • Cheng, L., Zhou, Z., Flesken-Nikitin, A., Toshkov, I. A., Wang, W., Camps, J., Ried, T. and Nikitin, A. Yu. (2010). Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene 29:5700-5071.
  • Choi, J., Curtis, S., Roy, D. M., Flesken-Nikitin, A., and Nikitin, A. Yu. (2010). Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. J. Pathology. 177:2645-2658.
  • Kaufman M. H., Nikitin, A. Yu., and Sundberg, J. P. (2010). Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis. CRC Press. Boca Raton, FL., 232 p.
  • Zhou, Z., Flesken-Nikitin, A. and Nikitin, A. Yu. (2007). Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res. 67:5683-5690.
  • Liao, C.-P., Zhong, C., Saribekyan, G., Bading, J., Park, R., Conti, P. S., Moats, R.,  Berns, A., Shi, W., Zhou, Z., Nikitin, A. Yu., and Roy-Burman, P. (2007). Mouse models of prostate adenocarcinoma with capacity for monitoring spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 67:7055-7546.
  • Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W. and Nikitin, A. Yu. (2007). MicroRNA-34b and -34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433-8438.
  • Zhou, Z., Flesken-Nikitin, A., Corney, D. C., Wang, W., Goodrich, D. W., Roy-Burman, P. and Nikitin, A. Yu. (2006). Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res. 66:7889-7898.
  • Zhou, Z., Flesken-Nikitin, A., Levine, C. G., Shmidt, E. N., Eng, J. P., Nikitina, E. Yu., Spencer, D. M., and Nikitin, A. Yu. (2005). Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary anterior lobe tumors and medullary thyroid carcinomas in Rb+/- Cancer Res. 65:787-796.
  • Flesken-Nikitin, A., Choi, K.-C., Eng, J. P., Shmidt, E. N. and Nikitin, A. Yu. (2003). Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res., 63: 3459-3463.